If you had any piece of the New York Giants-Detroit Lions matchup in Week 12 in fantasy football, we hope it was RB Jahmyr Gibbs. In what should go down as the wildest games of the week, the Lions lead back narrowly edged out Colts RB Jonathan Taylor for the best single-game performance of the fantasy season.

Some different players get the spotlight this week as we highlight some of the best from the Week 12 fantasy football leaderboard.

Jahmyr Gibbs 55.4 PPR points. Jaxon Smith-Njigba 37.1 points. Hunter Henry 24.5 points. What do these Week 12 scores have in common besides being extraordinarily good point totals? They all occurred against favorable mismatches for those players.

Jahmyr Gibbs, Jaxon Smith-Njigba and Emanuel Wilson led the way with big Week 12 performances, while Jonathan Taylor, Josh Allen and Lamar Jackson and were among the biggest disappointments.

Sunday saw Smith-Njigba haul in eight catches for 167 yards and two touchdowns, putting him over 1,300 yards for the season. He has already set the Seahawks franchise record for receiving yards in a season with six games still left to be played.

These NFL teams have very high-scoring potential in Week 12. Look to their fantasy players, such as Matthew Stafford and Jahmyr Gibbs, to produce big.

Michael Salfino shares his observations for Week 10, including a long-awaited breakout effort from New England rookie TreVeyon Henderson.

The fantasy football season continues, and with the weather getting colder and harsher around the country, running backs will begin to become much more key for many teams.

Bijan Robinson and Jahmyr Gibbs lead UPI senior sports writer Alex Butler's Top-50 fantasy football running back rankings for Week 12 of 2025.

The Detroit running back stuffed the stat sheet against the Giants, while a pair of Vikings players fell flat as J.J. McCarthy’s struggles continued.