The episode also pokes fun at the purported “Epstein list,” a client roster of high-profile individuals supposedly linked to convicted sex trafficker Jeffrey Epstein.

“South Park” was in vintage form on Wednesday night, as the long-running animated comedy series did not hold back during its season 27 premiere.

“This show hasn’t been relevant for over 20 years and is hanging on by a thread with uninspired ideas in a desperate attempt for attention,” White House spokesperson Taylor Rogers said in a statement...