Monday Night Football, 49ers and Panthers
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NFL, in Panthers and Baker Mayfield
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Carolina is coming off an unusual offensive game wherein it did not run the ball particularly well but absolutely exploded in the passing game. The Panthers ran for just 67 yards last week against the Falcons, but Bryce Young went an incredible 31 of 45 for 448 yards and three touchdowns.
Brock Purdy is back, and the San Francisco 49ers are 7-4 this season after blowing out the Arizona Cardinals in Purdy’s third start of the 2025 season. With his
Panthers vs. 49ers will broadcast nationally on ESPN/ABC in Week 12 of the 2025 season. Joe Buck (play-by-play commentator), Troy Aikman (color analyst), Lisa Salters (sideline reporter) and Laura Rutledge (sideline reporter) are on the call.
How to watch this week's Monday Night Football game between the Carolina Panthers and the San Francisco 49ers.
Oct 9, 2022; Charlotte, North Carolina, USA; San Francisco 49ers running back Jeff Wilson Jr. (22) runs for yardage pursued by Carolina Panthers cornerback Jaycee Horn (8) during the first quarter at Bank of America Stadium. / Jim Dedmon-Imagn Images
The San Francisco 49ers have transformed their offense since acquiring Christian McCaffrey from the Carolina Panthers three years ago.