You've seen the model's best bets for Indianapolis Colts vs. Kansas City Chiefs. Now, get against the spread, total and money-line picks for every Week 12 NFL game here, all from the model that's simulated every game 10,000 times.

The Indianapolis Colts visit the Kansas City Chiefs today, Nov. 23, 2025, in NFL Week 12 action. Who's in and who's out?

Patrick Mahomes secured the 35,000 passing yards mark in 123 games with the Kansas City Chiefs. The previous record holder was former Detroit Lions star and current Los Angeles Rams quarterback, Matthew Stafford, who achieved the feat in 126 games.

The Indianapolis Colts had the Kansas City Chiefs in a bind until late in their matchup Sunday, when they went away from Jonathan Taylor and put the game in Daniel Jones' hands.

The Indianapolis Colts announced they have officially activated cornerback Charvarius Ward Sr. from injured reserve after the starter missed four games due to a concussion. The team also announced that they have waived cornerback Cameron Mitchell.

An Indianapolis Colts insider has shut down some rather alarming Daniel Jones news that surfaced before Week 12.

Tom Pelissero of the NFL Network put together his list of the 24 young head coaching candidates to know in 2026, and included was Indianapolis Colts' offensive coordinator Jim Bob Cooter.

The Indianapolis Colts have the fourth-best odds to win Super Bowl LX at +900, trailing only the Los Angeles Rams and Philadelphia Eagles — and they sit as the outright favorite to win the AFC at +400,