George Kittle is hot, and the run is expected to extend on Monday Night Football against the Carolina Panthers. Thomas Valentine of Pro Football Focus went through the matchup to watch on the game and noted that Kittle may be have a great opportunity.

Preview the Week 12 matchup between the San Francisco 49ers and Carolina Panthers with predictions, odds, over/under, spread, betting lines and more.

The San Francisco 49ers will take on the Carolina Panthers on Monday night, but they'll be without another edge rusher due to injury.

The San Francisco 49ers have a big matchup against the Carolina Panthers that will swing the playoff odds in a big way. If the 49ers want to walk out of Week 12 with an 8-4 record and an easy walk into the playoffs, they need a few key names to become big-time players .

The San Francisco 49ers have transformed their offense since acquiring Christian McCaffrey from the Carolina Panthers three years ago.

The 49ers (7-4) are seeking a second straight win Monday night when they host the upstart Carolina Panthers (6-5).

Oct 9, 2022; Charlotte, North Carolina, USA; San Francisco 49ers running back Jeff Wilson Jr. (22) runs for yardage pursued by Carolina Panthers cornerback Jaycee Horn (8) during the first quarter at Bank of America Stadium. / Jim Dedmon-Imagn Images