Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease

As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment.
Healio

FDA efforts to reduce animal testing signal shift toward AI, organ-on-chip study methods

In April 2025, the FDA announced plans to shift biomedical research for monoclonal antibodies and other medications away from animal testing toward new approaches. One year later, much speculation ...
GEN

Humanized Animal Models Boost Translational Value

Due to advancements in genetic engineering, small animal models are continuing to change in response to market needs. Model developers strive to better reflect the role of this important asset in both ...
National Academies of Sciences%2c Engineering%2c and Medicine

Advancing Disease Modeling Techniques in Animal-based Research in Support of Precision Medicine: A Workshop

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...
STAT

Modern animal models for biomedical research remain far better than alternatives

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...
National Academies of Sciences%2c Engineering%2c and Medicine

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop

Suggested Citation: "1 Introduction to Precision Medicine and Animal Models." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Disease Modeling in Animal-Based Research in ...