The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness.

The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...

IT is well established that an increase in the intracellular concentration of ionized calcium after excitation in the membrane is the key factor for initiation of contraction of various types of ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...