Biochemistry and cell biology investigate the molecular underpinnings of life, spanning the structure, function and interplay of biomolecules within cells. At its core, biochemistry elucidates the ...

Macrophages use cell‑volume changes to sense danger, reprogram gene expression, and heighten inflammatory and antiviral ...

Nicotinamide adenine dinucleotide (NAD+) has long been conceptualized as a ubiquitous redox cofactor, embedded deeply within metabolic frameworks across living systems. More recent biochemical ...

Medical biochemistry unravels the molecular foundations of health and disease by examining small-molecule metabolism, enzyme function and cellular signalling. Metabolomics extends this enquiry by ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Researchers have shown that the formation of biological condensates affects cellular activity far beyond their immediate vicinity. The results show that they may be a previously missing mechanism by ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

A key molecular dynamic could be the key to fighting tumors while allowing patients to still receive life-saving cell transplantation, according to the latest finding published by a team of scientists ...

In this Research Topic, we aim to highlight examples of vanadium science as it applies to Chemical Biology, focusing on vanadium chemistry discussed at the ...

Illustration of a dimer protein structure. A structure of the stimulator of interferon genes (STING) dimer shows how it binds to a phosphatidylinositol species. Credit: Nature The work suggests new ...