The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible ...

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

DNA isn't just a long string of genetic code, but an intricate 3D structure folded inside each cell. That means the tools used to study DNA need to be just as sophisticated-able to read not only the ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

Although every cell in the body contains the same genetic sequence, only a subset of genes is expressed in each cell. This selective gene expression, which differentiates a brain cell from a skin cell ...

A robust platform for analyzing 3D genome architecture and epigenomic features enables a deeper understanding of gene regulation in specific cell types. Researchers analyze various aspects of gene ...

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed. The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a ...