Single-cell RNA sequencing of endometrial samples across the menstrual cycle identified key cell types and gene signatures ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

This article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and ...

GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

A fleeting DNA fold called i‑DNA can switch cancer‑related genes on and off, revealing a hidden structural weak point that future therapies might exploit to collapse tumors.

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

Real-World Plasma Thymidine Kinase Activity in High-Risk and Metastatic Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Treated With Cyclin-Dependent Kinase ...

Gene therapy has been successfully used to treat a number of diseases, including immune deficiencies, hereditary blindness, ...