Central nervous system (CNS) toxicity accounts for 25% of safety failures across drug discovery and development, yet it is rarely detected during standard GLP toxicology studies 1. Seizure risk ...

The Forum on Neuroscience and Nervous System Disorders hosted a public workshop on June 21-22, 2010, bringing together key stakeholders, to present promising current and emerging technologies with ...

Inflammatory pathways involving microglia, astrocytes, and cytokine signaling are widely implicated in disorders including Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, and ...

• Establishing pharmacologically relevant exposure levels and engagement are two key steps in target validation. • There is a need for better biomarkers to objectively measure biological states and ...