DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...

A subset of DNA helicases, the RecQ family, has been found to be associated with the p53-mediated apoptotic pathway and is involved in maintaining genomic integrity. This family contains the BLM and ...

Scientists who study biological systems at the molecular level have over the years looked to the structure of protein molecules-how the atoms are organized-to shed light on the diverse functions each ...

The structure of the RecBCD helicase, although not hexameric, shows how the action of the motor pulls the DNA across amino acid residues that serve as a wedge to separate the duplex 12. A similar ...

(Nanowerk News) Scientists have long known that double-stranded DNA can be unwound into single-stranded DNA by molecular motor proteins called helicases, just like pulling a zipper. But researchers at ...

In a recent study published in the PNAS Journal, researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication. They characterized the ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...

New research shows that the nuclease domain of the E. coli RecBCD helicase plays a key role in regulating DNA binding and the extent of base pair melting during double-strand break repair. Deleting ...

Researchers have identified the mechanism used by the helicase ring to thread around and separate entwined DNA strands in the replication process. DNA replication is a complex process in which a ...