When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Researchers at Umeå University show how tick-borne viruses remodel human cells into virus factories, using an advanced microscopy method. The findings provide new insight into how the virus replicates ...

In each cell of your body, DNA is stored in structures called chromosomes. When cells divide, these chromosomes are copied, ...

The modulation of DNA replication dynamics has emerged as a key area of study in understanding genome stability and its perturbations in various physiological and pathological contexts. Replication ...

It's tricky to make an exact copy of yourself. Or at least it is for cells undergoing mitosis, where cells replicate everything inside of them, including their neatly packaged DNA, then split in half.

Cancer cells frequently rely on backup mechanisms and alternative, often mutagenic, pathways to repair DNA damage. These adaptations enable cancer cells to survive and proliferate in hostile ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Single-cell analysis helps uncover how the BK virus replicates, opening the door to new drug targets. BK polyomavirus (BKPyV) is a major cause of kidney transplant failure. Without a complete ...

Glucose is the fuel to the cellular engine. It powers the cell’s functions and serves as the raw material for synthesizing various essential biomolecules, including the sugar backbone of DNA and RNA.