Genome editing-based therapies typically aim to treat disease by correcting underlying genetic mutations in patient's cells.

Work has begun on something once-unthinkable: creating human DNA from scratch. Artificial DNA has long been an ethical minefield, with fears of a generation of ‘designer babies’ with pick ‘n’ mix ...

Researchers have found hundreds of metabolic enzymes attached to human DNA inside the cell nucleus. Different tissues and cancers show unique patterns of these enzymes, forming a “nuclear metabolic ...

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle ...

A new method for safely inserting large chunks of DNA into genomes has now measured up in mice, potentially paving the way ...

Researchers have used a new human reference genome, which includes many duplicated and repeat sequences left out of the original human genome draft, to identify genes that make the human brain ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...