Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use. Featured in the February ...

Objective Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design ...

Four years after its discovery, the weight-controlling protein hormone leptin is still making news. At the American Diabetes Association meeting in Chicago June 14, researchers from Amgen Inc. of ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

A paper published in the May issue of Diabetes implicates triglycerides in the mechanism of leptin resistance. These fats, elevated in obesity, are what disrupt the transport of the hormone across the ...

Obesity is not a single disease. New research shows distinct biological phenotypes that explain why weight gain and treatment ...

Your defended weight range can gradually shift upward through hormonal, metabolic, environmental, and microbiome-driven changes that push the body toward higher weight. Questions about why weight gain ...