The most common side effects of mRNA vaccines like the COVID-19 shot are well known: soreness, mild fever, and general ...

Alzheimer's disease (AD) is characterised by progressive neurodegeneration and cognitive decline, with emerging evidence implicating disruptions in lipid metabolism as a central element in its ...

Lipid metabolism and storage mechanisms underpin essential cellular processes, ensuring energy homeostasis and membrane integrity. At the cellular level, lipids are synthesised and stored ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Variability among lipids affects cellular metabolism, signaling pathways, energy storage, and cell membrane structures. Therefore, it’s important for biomanufacturers to have an accurate, ...