The Week 12 NFL schedule is headlined by the ever-continuing saga of the Kansas City Chiefs against the AFC South-leading Indianapolis Colts on Nov. 23. Kansas City is 5-5 after losing on a last-second field goal at Denver and returns home in need of a run.

NFL regular season officially kicks off on Thursday, November 20, with a primetime AFC showdown between the Buffalo Bills and Houston Texans at NRG Stadium on Prime Video. Houston will be without star quarterback CJ Stroud for a third straight game as he remains in concussion protocol,

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The Los Angeles Rams and Tampa Bay Buccaneers will duke it out in a highly anticipated matchup between star quarterbacks in Week 12 of the NFL season.

See the top projected fantasy wide receivers for Week 12. Our rankings highlight the best WR options to start in your fantasy football lineup.

The Detroit Lions host the New York Giants in Week 12 of the 2025 NFL season on Sunday. There are several ways fans can watch and stream Sunday's game.

What just happened? What does it mean? What are the pertinent factors (and, perhaps, tiebreakers) prominently in play as each conference's seven-team bracket begins to crystallize? All will be explained and analyzed up to the point when the postseason field is finalized on Sunday,

See the top projected fantasy quarterbacks for Week 12. Our rankings highlight the best QB options to start in your fantasy football lineup.