We have officially reached the closing stretch of the 2025 regular season. It’s crunch time. The Saturday Down South staff returns to give their ATS picks for the top Week 12 college football games. Let’s dive in. (Editor’s note: All odds for this piece might not necessarily reflect current odds.)

Miami (FRONT-RUNNER PROFILE): Miami has been strong this season and sits at ~7–2 with top-25 consideration; they’re playing a home Senior Day spot and have a stout overall profile, particularly on defense and special teams. Their season momentum and SP+ ranking underline why books favor them by a large number.