New Assay Expands INDIGO’s GPCR Portfolio and Supports Development of Next-Generation CNS-Related Therapeutics STATE ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has revealed how a tryptophan-rich allosteric communication network regulates ...

Researchers have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a new study. The findings hold ...

Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...

A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases. A team led by LMU researchers Christian Weber and Yvonne Döring has demonstrated ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Researchers at the University of California San Diego have uncovered how a single protein triggers two opposite responses in blood vessels—one inflammatory and one protective. This protein, a ...

Results from Phase 2 clinical studies, CHAPTER-1 and RAPIDe-1, provide evidence of viability of bradykinin B2 receptor antagonism in management ...

Image of a cortical neuron (white) expressing serotonin 2A (5-HT2A) receptors (multicolor). New work shows that engaging 5-HT2A receptors inside cells, but not on the cell surface, encourages cell ...

Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Researchers at the NYU Pain Research Center have found a new receptor for ...