Which NFL DFS picks from those matchups should you target, and are there players from potentially lower-scoring games like Seahawks vs. Titans or Raiders vs. Browns who should factor into your NFL DFS strategy?

Jamie's DraftKings NFL DFS Week 12 picks, value plays, DFS sleepers for the main slate (2025). His top DK plays and value picks for daily fantasy football lineups.

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The Colts are coming off their bye week and the Chiefs have lost two straight. Kansas City is 0-5 in one-possession games.