Having not played since Week 8 -- when his stats were: 12 carries, 58 yards -- Isiah Pacheco and the Kansas City Chiefs will face the Indianapolis Colts in Week 12, on Sunday at 1 p.m. ET. Game Time: 1 p.m.

When is Isiah Pacheco coming back? Will Isiah Pacheco play again this season? Read about Isiah Pacheco's return date and injury updates for 2025 as of Week 12.

Kansas City Chiefs starting running back Isiah Pacheco returned to practice Wednesday after missing games against the Buffalo Bills and Denver Broncos because of an MCL sprain. During the brief portion of practice open to reporters, Pacheco was seen wearing a sizable brace on his right knee.

Pacheco missed the last two weeks with a knee injury, but he was listed as a full participant as the Chiefs got to work ahead of this weekend’s game against the Colts. If he maintains that level of participation the rest of the week, it would be a good sign that he’ll be ready to go on Sunday.

Running back Isiah Pacheco (knee) will miss his third straight game for the Chiefs, but left guard Kingsley Suamataia and wide receiver Xavier Worthy are active against the Indianapolis Colts.

Pinkston knows what Reid looks for in a player: he was a wide receiver for the Philadelphia Eagles during the first five seasons of Reid’s tenure as head coach. He is now in his third season as Kansas City’s running backs coach and has a good feel for what skills the Chiefs’ top offensive mind wants from the position.