Nov 20, 2025; Houston, Texas, USA; Buffalo Bills quarterback Josh Allen (17) walks off the field after a play during the game against the Houston Texans at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images / Troy Taormina-Imagn Images

Texans (+5.5) over Bills. Buffalo's defense is reeling at the moment, allowing 30 or more points in back-to-back games. The Bills' run defense has been abysmal, surrendering 5.4 yards per carry (second most in the NFL). That could result in a strong day for the Texans on the ground, which could help tip the scales in favor of an upset.

After a dud performance on Thursday Night Football, which included getting hurt, Josh Allen’s repeat MVP campaign is all but done, according to oddsmakers.  The

Laramie, Wyoming (War Memorial Stadium) Date/Time: Saturday, November 22nd at 12:00 p.m. (Mountain Time) Television: Mountain West Network Streaming: Mountain West App Radio: KOWB 1290 AM/95.1 FM/KOWB App (Cowboy Sports Network) Head-to-Head: Wyoming leads the all-time series 6-4,

Will Anderson Jr. continues to be a terror for opposing quarterbacks en route to a Defensive Player of the Year season with the Houston Texans.