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Cavaliers vs. Pacers odds, prediction: 2025 NBA picks for Friday, November 21 from proven model
Tipoff is set for 7 p.m. ET in Cleveland. Cleveland is a 13.5-point road favorite in the latest Cavaliers vs. Pacers odds, while the over/under is 238.5. Before making any Pacers vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.
Indiana's defense will be dominated by Donovan Mitchell tonight, as our Pacers vs. Cavaliers picks, odds & expert predictions for Friday, November 21 explain.
The Indiana Pacers and Cleveland Cavaliers meet Friday at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET.