The Horned Frogs (7-4, 4-4 Big 12) jumped out to a 14-0 lead in the first quarter, but allowed the Cougars (8-3, 5-3), who are No. 23 in the College Football Playoff rankings, back into the game with four turnovers and multiple penalties that wiped touchdowns off the board.

Houston football lost its final home game of the season 17-14 to the TCU Horned Frogs on Saturday evening, inside TDECU Stadium, in Houston, Texas. Houston’s of

College football Week 13 odds, picks, predictions, TV channel, streaming for TCU Horned Frogs vs Houston Cougars game on Saturday, Nov. 22, 2025.

The TCU Horned Frogs (6-4, 3-4 Big 12) and Houston Cougars (8-2, 5-2) tangle in Big 12 action Saturday. The contest at TDECU Stadium in Houston, Texas, will kick off at 4 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NCAA football odds around the TCU at Houston odds and make our expert college football picks and predictions for the best bets.