A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...

GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

Commercial sales and marketing agreement enhances 3RnD’s mechanistic toxicity screening panel, and expands the reach of ...

This article and associated images are based on a poster originally authored by Sam Hoare, Luciana Leo, Anastasia Schultz, and Thom Hughes and presented at ELRIG Drug Discovery 2025 in affiliation ...

Luciferase-based reporter cell lines are invaluable for detecting cellular responses to signaling pathways in vitro, enabling high-throughput screening and profiling of inhibitors or activators. In ...

Chemerin is a key adipokine—a signaling protein released by adipose tissue—that regulates lipid metabolism and insulin sensitivity and thus is involved in many metabolic diseases such as obesity and ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). Subscribe to our newsletter ...