Pulmonary arterial hypertension, or PAH, is a rare and severe disease characterized by elevated blood pressure in the ...

Twenty years after the publication of Fontan's landmark article, he and his colleagues [16] warned about the long-term results of the Fontan operation, expressing the fear that continuing attrition ...

Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical ...

Researchers may have found a key mechanism underlying idiopathic pulmonary fibrosis, a usually fatal lung disease for which transplantation is the only successful treatment. The investigators found ...

Three major pathways involved in abnormal proliferation and contraction of the smooth-muscle cells of the pulmonary artery in patients with pulmonary arterial hypertension are shown. These pathways ...

Most patients with familial primary pulmonary hypertension have defects in the gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming growth factor β (TGF-β) superfamily ...

The Fontan operation and its variants have become the procedures of choice in patients with one anatomical or functional ventricular chamber. In a normal biventricular heart, the systemic and ...