Researchers highlight role of alternative RNA splicing in schizophrenia

In an important new study, researchers led by LI Ming from the Kunming Institute of Zoology of the Chinese Academy of Sciences have discovered the previously unrecognized role of alternative splicing ...
JSTOR Daily

Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...
BioWorld

RNA-targeting CRISPR-Cas13 and engineered U1 correct variants in Stargardt disease

Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...
BioWorld

Vigeneron’s mRNA trans-splicing gene therapy for Stargardt disease receives IND clearance

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...
Health And Pharma

Rewiring RNA: Antisense RNA Therapy Exposes a New Weakness in Pancreatic Cancer

Researchers at CSH Laboratory identified an oncogenic SRSF1–AURKA–MYC circuit driving pancreatic ductal adenocarcinoma.
Fred Hutch

RNA “typos” can highlight leukemia cells for immune attack

Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...