Week 13 of the 2025 college football season kicks into full swing on Saturday afternoon with some exciting matchups across the country. Saturday’s schedule includes two ranked vs. ranked matchups, including four top 20 showdowns.

USC can keep its College Football Playoff hopes alive and could put Oregon's playoff chances in some jeopardy with a victory.

The Ducks have a 71.9% chance to win and are favored by 10.5 points - a lot of money in the spread has moved toward Oregon.