The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

Explore the top DraftKings Showdown RB options for Panthers vs. 49ers, including analysis on Christian McCaffrey and Rico ...

The Panthers travel to San Francisco in search of their fourth consecutive road victory. The franchise has not won four straight road games within a season since winning their first seven road games ...

Week 12 MNF features two NFC teams vying for playoff spots. They both still have a chance to win their division, but it’s a ...

In 2024, the San Francisco 49ers running-back McCaffrey tied the knot with Olivia Culpo, a model, actress and former Miss Universe.

Panthers vs. 49ers Picks is the kind of keyword you want to read before locking totals — this matchup has volatile offenses, ...

There aren't many players in the NFL who are more dynamic than Christian McCaffrey. The dual-threat running back has rushed ...

For the first time all season, the Panthers are playing after the sun has gone down. And that’s not the only first they will ...

A ton of intriguing player prop targets face off on Monday night in Week 12 of the 2025 season, as the San Francisco 49ers ...

Week 12 of the NFL season concludes with a Monday Night Football tilt between the Carolina Panthers and San Francisco 49ers.

USA Today's NFL experts make their picks for a Week 12 showdown between the San Francisco 49ers and Carolina Panthers ...

The San Francisco 49ers welcome the Carolina Panthers to Levi's Stadium on Monday night. The banged-up defense will be tested ...