For the second week in a row, the 49ers will face an offense in the top five in plays per drive. And while Carolina runs just about the same number of plays per drive as the Cardinals do – Carolina runs 6.4 plays per drive compared to Arizona’s 6.5 – the Panthers score much less frequently than the 49ers’ Week 11 opponent.

Dave Canales’s team got a big assist from the Los Angeles Rams on Sunday. The Carolina Panthers will lead the NFC South if they beat the 49ers on Monday night.

CMC faces his old team for the first time. Here's your "Monday Night Football" warmup ahead of tonight's Panthers-Niners game.

Only two of the NFL's 32 general managers played in the league -- and they took drastically different paths to get there.

The San Francisco 49ers have transformed their offense since acquiring Christian McCaffrey from the Carolina Panthers three years ago.

The 49ers packaged a second-, third- and fourth-round pick in 2023 and a fifth-rounder in 2024 for McCaffrey from the Panthers.

Oct 9, 2022; Charlotte, North Carolina, USA; San Francisco 49ers running back Jeff Wilson Jr. (22) runs for yardage pursued by Carolina Panthers cornerback Jaycee Horn (8) during the first quarter at Bank of America Stadium. / Jim Dedmon-Imagn Images

The 49ers will be without record-setting kicker Eddy Piñeiro against the Panthers, as San Francisco rules him out for Monday Night Football.