Scientists discover a rare genetic quirk that may extend the age of onset in people with Huntington’s disease by boosting ...

To better understand how the MutSβ complex can make the DNA zipper worse, the authors used a technique called cryo-electron ...

SOM3355 is still an investigational drug, and only a Phase 3 trial can determine whether it is safe and effective enough to seek approval. But the combined momentum from the EMA and FDA reflects a ...

A small study from Brazil tested whether stem cells from human dental pulp, the soft tissue inside teeth, could help people with Huntington’s disease (HD). The results hint at small improvements on ...

Why do some people with intermediate CAG repeats, a genetic “gray zone” in Huntington’s disease, develop neurological symptoms while others do not? This article covers a recent study that tackled this ...

A BLA, or Biologics Licensing Application, is the formal dossier of information that a company uses to request permission to market a biologic, which is a therapy created from living organisms, like ...

A new study in mouse models reveals how Huntington’s disease (HD) disrupts brain development over time, even long before symptoms appear. Using advanced sequencing tools and spatial transcriptomics, a ...

This month brought new revelations across biomarkers, basic science and community gathering. In particular, we saw how DNA-repair targeting strategies are moving into focus, how gaps in diagnosis are ...

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Sonia Vázquez-Sánchez is a neuroscientist from Madrid, Spain. After studying biology in Madrid and completing her Neuroscience PhD in Amsterdam, she moved to San Diego for postdoctoral research. Her ...