Gut

Acute upper gastrointestinal bleeding in the UK: 2022 audit update

Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and ...
Gut

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...
gut.bmj

Multicentre prospective evaluation of real-time optical diagnosis of T1 colorectal cancer in large non-pedunculated colorectal polyps using narrow band imaging (the OPTICAL study)

Correspondence to Dr Leon M G Moons, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands; ...
gut.bmj

Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification

Dr L Lundell, Department of Surgery, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. BACKGROUND Endoscopic oesophageal changes are diagnostically helpful and identify patients exposed to ...
gut.bmj

Development and validation of the Nancy histological index for UC

2 Inserm U954, Genetic Nutrition and Exposure to Environmental Risks (NGERE), University of Lorraine, Vandoeuvre- lès-Nancy, France Correspondence to Professor Laurent Peyrin-Biroulet, Inserm U954 and ...
gut.bmj

Eosinophilic oesophagitis: a novel treatment using Montelukast

1 Department of Upper Gastro-intestinal Surgery, Hope Hospital, Salford Royal Hospitals NHS Trust, Manchester, UK 2 Department of Pathology, Hope Hospital, Salford Royal Hospitals NHS Trust, ...
gut.bmj

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

Objective In the liver, the transcription factor, Kruppel-like factor 2 (KLF2), is induced early during progression of cirrhosis to lessen the development of vascular dysfunction; nevertheless, its ...
gut.bmj

Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

Department of Pathology, University Hospital Gasthuisberg, Catholic University Leuven, Belgium Dr D Sifrim, Faculty of Medicine, KU Leuven, Lab G-I Physiopathology, O & N Gasthuisberg 1, Herestraat 49 ...
gut.bmj

The gut microbiota, dietary extremes and exercise

The GI tract is colonised by trillions of bacteria in a complex community collectively referred to as the gut microbiota. This metabolically active ‘foreign’ body contributes to host metabolism and ...
gut.bmj

Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management

Delayed gastric emptying can be due to muscular, neural, or humoral abnormalities. In the absence of an identified cause, gastroparesis is labelled as idiopathic. We present the case of a patient with ...
gut.bmj

Pregnancy in primary sclerosing cholangitis

10 Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 11 Department for General and Thoracic Surgery, University Medical Center ...
gut.bmj

Corpus gastritis is protective against reflux oesophagitis

Department of Veterans Affairs Medical Centre, University of New Mexico, Albuquerque, New Mexico, USA Dr A Sonnenberg, Department of Veterans Affairs Medical Centre 111F, 1501 San Pedro Drive SE, ...