Gut

Acute upper gastrointestinal bleeding in the UK: 2022 audit update

Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and ...
Gut

Gut microbiome in IBD: past, present and the future

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...
Gut

FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...
Gut

Thrombospondin-2: a promising but unproven biomarker for MASH

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide, reflecting the growing prevalence of obesity and type 2 diabetes. Some patients ...
gut.bmj

Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study

A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and ...
gut.bmj

Multicentre prospective evaluation of real-time optical diagnosis of T1 colorectal cancer in large non-pedunculated colorectal polyps using narrow band imaging (the OPTICAL study)

Correspondence to Dr Leon M G Moons, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands; ...
gut.bmj

Eosinophilic oesophagitis: a novel treatment using Montelukast

1 Department of Upper Gastro-intestinal Surgery, Hope Hospital, Salford Royal Hospitals NHS Trust, Manchester, UK 2 Department of Pathology, Hope Hospital, Salford Royal Hospitals NHS Trust, ...
gut.bmj

STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT

1 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK 2 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK and Molecular Pathology Centre, Institute of ...
gut.bmj

Development and validation of the Nancy histological index for UC

2 Inserm U954, Genetic Nutrition and Exposure to Environmental Risks (NGERE), University of Lorraine, Vandoeuvre- lès-Nancy, France Correspondence to Professor Laurent Peyrin-Biroulet, Inserm U954 and ...
gut.bmj

Ultrastructural organisation of HCV from the bloodstream of infected patients revealed by electron microscopy after specific immunocapture

4 Plate-Forme IBiSA des Microscopies, PPF ASB, Université François Rabelais and CHRU de Tours, Tours, France Correspondence to Dr Jean-Christophe Meunier, INSERM U966, Faculté de Médecine, Université ...
gut.bmj

Systematic review: monotherapy with antitumour necrosis factor α agents versus combination therapy with an immunosuppressive for IBD

The treatment of IBD has evolved significantly over the past 15 years. Historically, steroids and immunosuppressive drugs, such as methotrexate (MTX), azathioprine (AZA) and 6-mercaptopurine (6-MP) ...
gut.bmj

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

Objective In the liver, the transcription factor, Kruppel-like factor 2 (KLF2), is induced early during progression of cirrhosis to lessen the development of vascular dysfunction; nevertheless, its ...