Background and objective Prior studies have suggested that patients with premature ventricular complexes (PVCs) may have an ...

Milestone articles have highlighted the frequency and types of statistical errors in research,1–5 yet fundamental errors ...

Background Mobility limitation is prevalent in patients with heart failure (HF), but the dose-response relationship between ...

Legalisation of medical and recreational cannabis commerce is spreading around the world, associated with increased use1 and falling perception of the risk.2 Frequent cannabis use has increased in ...

Background Emerging evidence suggests associations between air pollution, multimorbidity, and atrial fibrillation (AF), but their interplay remains unclear. We evaluated these relationships in a ...

Introduction Bicuspid aortic valve (BAV) affects 1% of the general population. NOTCH1 was the first gene associated with BAV. The proportion of familial and sporadic BAV disease attributed to NOTCH1 ...

Objective To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods Patients with a ...

The 2024 European Society of Cardiology (ESC) Guidelines on elevated blood pressure (BP) and hypertension reflect a shift from binary thresholds towards a risk-based management approach that aims to ...

Objectives (1) Describe how the risk of major adverse cardiovascular events (MACE) in individuals with chronic myeloid leukaemia (CML) has evolved; (2) evaluate the risk of MACE associated with the ...

Objectives This updated hierarchical Bayesian meta-analysis aims to integrate the latest randomised controlled trials (RCTs) on the use of cerebral embolic protection (CEP) in transcatheter aortic ...

Oxygen has been used in the treatment of myocardial infarction (MI) and acute coronary syndromes for over 100 years.1 The rationale for its longstanding use is that it increases oxygen delivery to the ...

In his song ‘Envelhecer’ (‘Aging’), Arnaldo Antunes states that “the most modern thing there is in this life is to grow old”.1 In this piece, he reframes aging not only as an inevitable biological ...