The Houston Astros could be losing their recently promoted rookie outfielder after he suffered an ankle sprain on Friday night.

The Houston Astros lost their decade-long anchor at third base in February when Alex Bregman bolted for Boston. Houston's new face at the hot corner has quickly quieted any concern over the future of the position.

1938 — Four days after pitching a no-hitter against the Boston Braves, Johnny Vander Meer of the Cincinnati Reds pitched his second straight no-hit game, defeating the Dodgers 6-0 in the first night game played in Brooklyn.

Near the end of a 10-3 blowout loss to the Houston Astros at Daikin Park that went awry early on Friday night, Lewis pulled up at first limping, due to what manager Rocco Baldelli called a “left hamstring strain of some kind.”

Isaac Paredes' hamstring injury hasn't forced him to the IL yet, but Jacob Melton's new ankle injury could lead to a prolonged absence.

So much has gone wrong for the Astros this year. Three-fifths of their season-opening rotation is on the injured list, and that doesn’t even count two other key starters who haven’t thrown a single pitch in 2025.

The Astros hope Isaac Paredes' hamstring strain is minor but Jacob Melton could be out longer after being injured Friday.

Chris Paddack was the latest Twins starting pitcher to struggle, giving up nine runs in four innings.