Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

Antibiotic resistance, especially in multidrug-resistant ESKAPE pathogens, remains a worldwide problem. Combination antimicrobial therapies may be an important strategy to overcome resistance and ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Among the characteristics shared by all extant living systems (1–3), their chemically controlled self-reproduction ranks perhaps as one of the most spectacular and exclusive.Under the control of their ...

All species have an environmental niche, and despite technological advances, humans are unlikely to be an exception. Here, we demonstrate that for millennia, human populations have resided in the same ...

Haplotype-resolved genome assemblies were produced for Chasselas and Ugni Blanc, two heterozygous Vitis vinifera cultivars by combining high-fidelity long-read sequencing and high‐throughput ...

The latitudinal diversity gradient (LDG) is the most prominent biodiversity pattern observed globally across most organisms ().The mechanisms underlying LDG remain debated, with many hypotheses ...

Studying E/I ratio development in vivo in humans is challenging due to limitations in noninvasive neuroimaging techniques. MR spectroscopy studies suggest changes in the balance of excitatory and ...

Low-energy electronic properties of few layer graphene (FLG) systems are known (1–8) to be strongly dependent on stacking arrangement.In bulk graphite 0° and 60° relative orientations of the ...

Autism spectrum disorder (ASD) is a complex neurological disorder characterized by social deficits and repetitive behaviors. Individuals with mutations in the Astrotactin 2 (Astn2) gene display a ...

This work was supported by NIH grants R01 DK031036 (to C.R.K.), in part by NIH training grant T32 DK007260 (to W.C.), and in part by the Steno North American Fellowship (NNF23OC0087108) awarded by the ...

In eukaryotes, genomic DNA is packaged into chromatin, which is the substrate for transcription, DNA replication, repair, and recombination. Within chromatin, nucleosomes contain two copies of each of ...