The synthesis of 2-methylcyclooctanone from cyclooctanone via enolate alkylation is a robust and well-established method for the α-functionalization of cyclic ketones.
Kinetic alkylation of 2-methylcyclooctanone (3.1a) proceeds with high stereoselectivity (> 95% trans). The addition of lithium dimethylcuprate to 8-methyl- cyclooct-2-en-1-one (3.1b) results in the clean …
22.7: Alkylation of Enolate Ions - Chemistry LibreTexts
The main determinant is whether the reaction is under kinetic control (rate) or thermodynamic control (equilibrium). Although a predominant product can be produced, a mixture of products is usually …
22.7 Alkylation of Enolate Ions – Organic Chemistry: A Tenth ...
Perhaps the most useful reaction of enolate ions is their alkylation by treatment with an alkyl halide, thereby forming a new C−C bond and joining two smaller pieces into one larger molecule.
The following tables summarize representative quantitative data for the synthesis of 2-Methylcyclooctanone. These values are based on typical yields and conditions for similar α-alkylation …
Transalkylation - an overview | ScienceDirect Topics
Trans- t -butylation and de- t -butylation reactions are facile processes, and form the basis of many applications of the t -butyl group as a positional protective group. This aspect was well reviewed by …
This technical support center provides guidance for researchers, scientists, and drug development professionals on scaling up the synthesis of 2-Methylcyclooctanone.