Which supplement is better Leucine an amino acid from the 3 Branched Chain Amino Acids or HMB and derivative of Leucine. Leucine is for building new muscle and stimulating muscle protein synthesis (MPS) where HMB a derivative of Leucine is more to prevent muscle breakdown under intense conditions like a caloric deficit or intense training. Both have their purposes and actually doing both together are ideal. Optimal dosages of leucine is 2-5grams per dose to stimulate MPS. HMB is typically recomm